Trend in ABO-incompatible RBC transfusion-related fatalities reported to the FDA, 2000-2019.

Background: ABO-incompatible red blood cell (RBC) transfusions and acute hemolytic reactions occur infrequently, yet resultant fatalities are reported to the US Food and Drug Administration (FDA) every year. We describe a 20-year retrospective study of reported mistransfusion cases to identify temporal trends, common causes, and corrective actions taken to prevent recurrence.

Study Design And Methods: ABO-incompatible RBC transfusion-related fatalities reported to the FDA in 2000-2019 were reviewed for patient demographics, primary attributed cause, contributing factors, and corrective actions.

Review of current transfusion therapy and blood banking practices.

Transfusion Medicine is a dynamically evolving field. Recent high-quality research has reshaped the paradigms guiding blood transfusion. As increasing evidence supports the benefit of limiting transfusion, guidelines have been developed and disseminated into clinical practice governing optimal transfusion of red cells, platelets, plasma and cryoprecipitate.

Spotlight on pathogenesis of TRALI: HNA-3a (CTL2) antibodies.

Human neutrophil antigen-3a (HNA-3a) antibodies contained in donor plasma can result in severe, sometimes fatal transfusion-related acute lung injury (TRALI). Recent developments in TRALI secondary to antibodies to HNA-3a antigen span diagnosis, pathophysiology, treatment, and prevention resulting in improved understanding, potential treatments, and mitigation strategies. First, on the molecular level, characterization of HNA-3 antigen has allowed for genotyping methods that clarify population prevalence.

contribution of genetically restricted, methicillin-susceptible strains to the ongoing epidemic of community-acquired Staphylococcus aureus infections.

Background: Within the current worldwide epidemic of community-acquired Staphylococcus aureus infections, attention has focused on the role of methicillin-resistant strains. We characterize methicillin-susceptible strains that also contribute to this epidemic.

Methods: We tracked cultures from abscess specimens submitted to the microbiology laboratory at St.

From rehabilitation to optimal function: role of clinical exercise therapy.

Purpose Of Review: Increasing numbers of critically ill and injured patients are surviving their initial hospitalization. The immobilization associated with long-term critical care can lead to deterioration of the musculoskeletal system within 6 h of bed rest, and muscle strength can decline by as much as 40% within a week of immobilization.

Recent Findings: The physical, emotional, and social deficits consequent to immobilization persist despite current rehabilitation, and a substandard quality of life following the event ensues for as long as 7 years post-trauma.