Impact of Laboratory-Adapted Intracellular Strains on the Activity Profiles of Compounds with Anti- Activity.

Chagas disease is caused by infection with the protozoan parasite, . The disease causes ~12,000 deaths annually and is one of the world's 20 neglected tropical diseases, as defined by the World Health Organisation. The drug discovery pipeline for Chagas disease currently has few new clinical candidates, with high attrition rates an ongoing issue.

Temporal and Wash-Out Studies Identify Medicines for Malaria Venture Pathogen Box Compounds with Fast-Acting Activity against Both and .

Chagas disease caused by the protozoan is endemic to 21 countries in the Americas, effects approximately 6 million people and on average results in 12,000 deaths annually. Human African Trypanosomiasis (HAT) is caused by the sub-species, endemic to 36 countries within sub-Saharan Africa. Treatment regimens for these parasitic diseases are complicated and not effective against all disease stages; thus, there is a need to find improved treatments.

Antiplasmodial Alkaloids from the Australian Bryozoan .

An extract from the bryozoan with antiplasmodial activity was identified through high-throughput screening of an Australian marine invertebrate extract library against . Chemical investigation of resulted in the isolation of six new brominated alkaloids, convolutamines K and L ( and ), volutamides F-H (-), and 2,5-dibromo-1-methyl-1-indole-3-carbaldehyde (). Three of the compounds (-) displayed moderate to potent antiplasmodial activity against both the chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) parasite strains of with an IC range of 0.

Change in postprandial substrate oxidation after a high-fructose meal is related to body mass index in healthy men.

Oral fructose decreases fat oxidation and increases carbohydrate oxidation in obese subjects, but the metabolic response to fructose in lean individuals is less well understood. The purpose of this study was to assess the effects of a single fructose-rich mixed meal on substrate oxidation in young healthy nonobese men. We hypothesized that a decrease in fat oxidation and an increase in carbohydrate oxidation would be observed after a fructose-rich mixed meal compared with a glucose-rich mixed meal.