Transitioning Professional Development Classes to Virtual Instruction.

The coronavirus disease 2019 (COVID-19) pandemic necessitated shifts in education delivery, forcing professional development specialists toward alternative learning delivery methods. Members of an academic-practice partnership at a Midwestern hospital collaboratively designed virtual evidence-based education modules for staff onboarding. We describe the transition from in-person education to online professional development.

4-Methylumbelliferone Inhibits Cancer Stem Cell Activation and Overcomes Chemoresistance in Ovarian Cancer.

We have recently shown that the extracellular matrix molecule hyaluronan (HA) plays a role in the development of ovarian cancer chemoresistance. This present study determined if HA production is increased in chemotherapy-resistant ovarian cancers and if the HA inhibitor 4-methylubelliferone (4-MU) can overcome chemoresistance to the chemotherapeutic drug carboplatin (CBP) and inhibit spheroid formation and the expression of cancer stem cell (CSC) markers. We additionally assessed whether 4-MU could inhibit in vivo invasion of chemoresistant primary ovarian cancer cells in the chicken embryo chorioallantoic membrane (CAM) assay.