How to Save a Limb: Identification of Pyoderma Gangrenosum.

We report the case of a 67-year-old woman with a painful expanding ulcer on the left leg of 2 months' duration that initially was diagnosed as a skin and soft tissue infection (SSTI) with plans for surgical debridement. Upon dermatologic consultation, surgery was canceled due to the possible diagnosis of pyoderma gangrenosum (PG) and risk of pathergy. Notable features of this patient included a history of inflammatory bowel disease (IBD), poor response to antibiotics, chronicity, lack of signs of sepsis, potential complications of surgical intervention, and ultimately a response to immunosuppressive agents.

Transient localized cutaneous reaction after onabotulinumtoxinA aesthetic injection.

OnabotulinumtoxinA (ONA) is an injectable neurotoxin frequently used to temporarily halt the skin changes associated with aging. Side effects are rare and usually minor, such as bruising, injection site discomfort, and headaches. However, a true hypersensitivity reaction is a serious adverse effect, and clinicians should not attempt another trial if allergy is suspected.

A Real-World Evaluation of the Long-Term Safety and Efficacy of Infliximab in the Treatment Moderate-to-Severe Psoriasis.

Introduction: Psoriasis is a chronic immune-mediated inflammatory skin disease that occurs in 2.5-3.5% of the general population.