Publications by authors named "Emily K Alley"
Article Synopsis
- Brain arteriovenous malformations (bAVMs) are risky blood vessel abnormalities in the brain caused by mutations, particularly in the KRAS gene.
- Research using mice models shows that these mutations lead to bAVMs in specific locations of the brain that match patterns found in humans, and these locations are tied to the likelihood of bleeding events.
- Blocking a specific pathway linked to KRAS mutations may offer a non-surgical treatment option for managing bAVMs, suggesting promising therapeutic approaches for affected patients.
Microvascular networks are challenging to model because these structures are currently near the diffraction limit for most advanced three-dimensional imaging modalities, including confocal and light sheet microscopy. This makes semantic segmentation difficult, because individual components of these networks fluctuate within the confines of individual pixels. Level set methods are ideally suited to solve this problem by providing surface and topological constraints on the resulting model, however these active contour techniques are extremely time intensive and impractical for terabyte-scale images.
View Article and Find Full Text PDF