Publications by authors named "Emily J Blake"
Article Synopsis
- PMS2 is a critical gene for DNA-mismatch repair linked to Lynch syndrome and certain cancers, making it a key target in genetic testing.
- The presence of the similar pseudogene PMS2CL complicates the sequencing process, often requiring costly long-read strategies instead of traditional methods.
- The article introduces a new bioinformatics workflow that can streamline PMS2 testing, eliminating the need for these more complex and expensive approaches for most patients.
Marine sponges play important roles in benthic ecosystems. More than providing shelter and food to other species, they help maintain water quality by regulating nitrogen and ammonium levels in the water, and bioaccumulate heavy metals. This system, however, is particularly sensitive to sudden environmental changes including catastrophic pollution event such as oil spills.
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- - DNA damage triggers a signaling network that can stop the cell cycle and promote repair or cell death, with chromatin structure playing a key role in how this response works.
- - Researchers used a high-content multiplex RNA interference screen to study the impact of chromatin-modifying genes on the DNA damage response, focusing on how these genes react to ionizing radiation.
- - The study highlights an isoform of Brd4 as an inhibitor of DNA damage signaling; its absence relaxes chromatin, allowing for faster cell recovery and increased survival post-radiation, while its presence does the opposite, suggesting Brd4's crucial role in regulating chromatin and DNA damage responses.
Objective: To determine pharmacokinetic profiles of two times a day and three times a day dosage regimens of Endometrin, a micronized progesterone vaginal insert for luteal support in assisted reproductive technology, compared with a gel.
Design: A single-center, randomized, open-label, single-day, and multiple-day (5 days) parallel design pharmacokinetic study.
Setting: University clinical research unit.
Objective: To evaluate vaginal compared to intramuscular (IM) progesterone supplementation for luteal phase support after in vitro fertilization and embryo transfer (IVF-ET).
Design: Retrospective matched-samples comparative study.
Setting: Private infertility center.
Objective: To assess the efficacy and safety of a vaginal progesterone (P(4)) insert (Endometrin) for luteal support for assisted reproductive technology (ART).
Design: Multicenter, randomized, open-label (assessor-blinded) phase III clinical trial.
Setting: Twenty-five U.