Publications by authors named "Emily Hills"
Mendelian randomization assessing causal relationship between fibrinogen levels and ischemic stroke.
J Stroke Cerebrovasc Dis
December 2024
Article Synopsis
- High fibrinogen levels are linked to a higher risk of ischaemic stroke (IS), suggesting a potential causal relationship explored using Mendelian randomization (MR).
- A meta-analysis involving 24 studies and over 20,000 IS cases revealed that certain gene variants (like FGB rs1800790) are associated with increased fibrinogen levels, which in turn raise IS risk.
- The analysis showed that each 1g/L increase in fibrinogen correlates with more than double the risk of experiencing an ischaemic stroke.
Aim: We systematically reviewed the literature to identify the benefits of early skin-to-skin contact (SSC) for all gestational ages.
Methods: The MEDLINE, Embase and CINAHL databases were searched for papers published in English from 1 January 1975 to 31 March 2020. Early SSC was defined as when the infant was placed directly onto the mother's chest within 180 min of birth.
Metastasized cancer cells have an increased resistance to therapies leading to a drastic decrease in patient survival rates. However, our understanding of the cause for this enhanced resistance is lacking. In this study, we report that physically tight confinement during cancer cell migration triggers therapeutic resistance and induces cancer stem cell-like behavior including up-regulation in efflux proteins and in cancer stem cell related markers.
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