Publications by authors named "Emily Henrich"
Lymph node (LN)-resident dendritic cells (DCs) are a promising target for vaccination given their professional antigen-presenting capabilities and proximity to a high concentration of immune cells. Direct intra-LN injection has been shown to greatly enhance the immune response to vaccine antigens compared to traditional intramuscular injection, but it is infeasible to implement clinically in a vaccination campaign context. Employing the passive lymphatic flow of antigens to target LNs has been shown to increase total antigen uptake by DCs more than inflammatory adjuvants, which recruit peripheral DCs.
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- Metastasis is the leading cause of death in breast cancer, necessitating an understanding of tumor cell migration and its correlation between in vitro and in vivo behavior.
- In a study using immunocompromised mice, six human triple-negative breast cancer (TNBC) cell lines were evaluated for their tumor growth, metastasis, and characteristics such as morphology, proliferation, and motility.
- The findings categorized cell lines by their metastatic potential and showed that morphological metrics were the best predictors of tumor growth and metastasis, while in vitro motility assays did not significantly correlate with in vivo outcomes.
Article Synopsis
- Metastasis is a major cause of death in breast cancer, involving processes like local invasion and colonization of distant organs, which are poorly understood across different human breast cancer cell lines.
- This study classified six triple-negative breast cancer cell lines in a mouse model based on their tumor growth and metastasis characteristics, revealing varying levels of tumorigenicity and metastatic potential.
- The researchers found that cell morphology metrics were the best predictors of metastasis, while no single motility assay consistently correlated with metastatic potential.