Publications by authors named "Emily Hasser"

Article Synopsis
  • Increased risk of venous thromboembolism (VTE) is a critical concern for individuals using oral contraceptives (OCs) or hormone therapy (HT), prompting research into genetic factors that may increase this risk.
  • A gene-by-environment case-only meta-analysis of genome-wide association studies (GWAS) examined genetic predispositions in OC and HT users, identifying potential risk variants associated with VTE events.
  • While primary GWAS results did not find significant genetic variants, the analysis of 138 candidate variants revealed two noteworthy associations: F5 rs6025 (previously noted) and F11 rs2036914 (newly identified), offering insight into genetic risks related to OC and HT use.
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Neither direct-to-consumer (DTC) genetic testing nor predictive genetic testing for adult-onset conditions is recommended for minor children due to ethical concerns and low clinical utility. However, parents with pathogenic variants (PVs) in disease-causing genes may be interested in pursuing genetic testing that includes the familial PV for their children. The Pediatric Testing Attitudes Scale (P-TAS) was previously developed to examine high-risk parents' opinions about pediatric BRCA genetic testing for adult-onset breast/ovarian cancer.

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