Evaluation of immediate vancomycin-induced hypersensitivity reaction to severe perioperative anaphylaxis.

The evaluation of vancomycin hypersensitivity reactions is challenging, as skin testing is not validated. Intradermal testing with vancomycin in human serum albumin-based sterile saline could be a new approach to the evaluation of IgE-independent hypersensitivity reactions.

One- versus 2-day aspirin desensitization in aspirin exacerbated respiratory disease: A quality improvement project.

Background: Current aspirin desensitization protocols for aspirin-exacerbated respiratory disease (AERD) require from 1 to 3 days to complete.

Objective: Our aim was to assess the implementation of a 1-day versus 2-day aspirin desensitization protocol in patients with aspirin-exacerbated respiratory disease.

Methods: We used a preintervention-postintervention quality improvement design to compare the completion rates, reaction rates, and estimated costs of a 2-day versus 1-day aspirin desensitization.