Publications by authors named "Emily Friis"
Article Synopsis
- Hematopoietic progenitor kinase 1 (HPK1) is an important target in immune oncology research because it regulates key signaling pathways in immune cells.
- Genetic deletion of HPK1 in T cells enhances their response to activation, and HPK1 knockout mice show improved anti-tumor effects.
- The study details the development of effective HPK1 inhibitors through structure-based drug design, achieving strong potency and increased IL-2 cytokine secretion, which could enhance anti-tumor immune responses.
A pH-independent quiet OmpG pore with enhanced electrostatic repulsion among the extracellular loops.
Biochim Biophys Acta Biomembr
January 2021
Membrane protein pores have emerged as powerful nanopore sensors for single-molecule detection. OmpG, a monomeric nanopore, is comprised of fourteen β-strands connected by seven flexible extracellular loops. The OmpG nanopore exhibits pH-dependent gating as revealed by planar lipid bilayer studies.
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