Publications by authors named "Emily F Davis"
Article Synopsis
- Small molecule therapies that target specific CFTR variants have transformed cystic fibrosis (CF) treatment.
- Researchers expressed 43 rare missense CFTR variants in CF bronchial epithelial cells, finding drug response correlated with CFTR function for ivacaftor and lumacaftor therapies.
- Most variants demonstrated greater effectiveness with the ivacaftor-lumacaftor combination therapy, suggesting that individuals with CF carrying these variants can potentially benefit significantly from these treatments, especially in combination.
The first total synthesis of Rolloamide B, a cyclic proline-enriched heptapeptide, is reported. This work features solution phase benzotriazole-mediated peptide synthesis ligating native amino acids.
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