Sustained in vivo perfusion of a re-endothelialized tissue engineered kidney graft in a human-scale animal model.

Despite progress in whole-organ decellularization and recellularization, maintaining long-term perfusion remains a hurdle to realizing clinical translation of bioengineered kidney grafts. The objectives for the present study were to define a threshold glucose consumption rate (GCR) that could be used to predict graft hemocompatibility and utilize this threshold to assess the performance of clinically relevant decellularized porcine kidney grafts recellularized with human umbilical vein endothelial cells (HUVECs). Twenty-two porcine kidneys were decellularized and 19 were re-endothelialized using HUVECs.

Effects of past language experience and present language context on the shape bias in Spanish-English bilingual children.

English-monolingual children develop a shape bias early in language acquisition, such that they more often generalize a novel label based on shape than other features. Spanish-monolingual children, however, do not show this bias to the same extent (Hahn & Cantrell, 2012). Studying children who are simultaneously learning both Spanish and English presents a unique opportunity to further investigate how this word-learning bias develops.