Preferred Language Mediates Association Between Race, Ethnicity, and Delayed Presentation in Critically Ill Patients With COVID-19.

Unlabelled: Which social factors explain racial and ethnic disparities in COVID-19 access to care and outcomes remain unclear.

Objectives: We hypothesized that preferred language mediates the association between race, ethnicity and delays to care.

Design Setting And Participants: Multicenter, retrospective cohort study of adults with COVID-19 consecutively admitted to the ICU in three Massachusetts hospitals in 2020.

Prolonged Prone Position Ventilation Is Associated With Reduced Mortality in Intubated COVID-19 Patients.

Background: Prone position ventilation (PPV) is resource-intensive, yet the optimal strategy for PPV in intubated patients with COVID-19 is unclear.

Research Question: Does a prolonged (24 or more h) PPV strategy improve mortality in intubated COVID-19 patients compared with intermittent (∼16 h with daily supination) PPV?

Study Design And Methods: Multicenter, retrospective cohort study of consecutively admitted intubated COVID-19 patients treated with PPV between March 11 and May 31, 2020. The primary outcome was 30-day all-cause mortality.

Code status orders in patients admitted to the intensive care unit with COVID-19: A retrospective cohort study.

Purpose: Code status orders impact clinical outcomes as well as patients' and surrogates' experiences. This is the first multicenter cohort examining code status orders of ICU patients with COVID-19 reported to date.

Materials And Methods: This is a retrospective cohort study including adult patients who tested positive for SARS-CoV-2 and were admitted to the ICU at three hospitals in Massachusetts from March 11, 2020 - May 31, 2020.

Jailers at the Bedside: Ethical Conflicts in Provision of Community Hospital Care for Incarcerated Individuals.

Incarcerated individuals in the United States are frequently transferred to hospitals in the community setting for specialized medical care beyond the capability of on-site facilities. Despite the widespread prevalence of this practice, hospitals set their own policies for the care of these vulnerable patients, which are often in conflict with broadly accepted principles of medical ethics. This article explores common practices of community hospitals in caring for incarcerated individuals and argues for the need for further research and, ultimately, reform in this neglected area.

A mathematical model of the Drosophila circadian clock with emphasis on posttranslational mechanisms.

Experimental evidence points increasingly to the importance of posttranslational processes such as phosphorylation and translocation in the molecular circadian clocks of many organisms. We develop a mathematical model of the Drosophila circadian clock that incorporates the emerging details of the timing of nuclear translocation of the PERIOD and TIMELESS proteins. Most models assume that these proteins enter the nucleus as a complex, but recent experiments suggest that they in fact enter the nucleus separately.