Publications by authors named "Emily E Leppien"

Article Synopsis
  • Women are under-represented in antipsychotic medication trials, leading to a study that evaluates five adverse events (AE) of first-generation antipsychotics (FGAs) using the FDA Adverse Event Reporting System (FAERS).
  • The study analyzed 24.6 million AE reports since 2000 and found varying reporting odds ratios (ROR) for different AEs between men and women, highlighting significant differences, especially for tardive dyskinesia (TD) and agranulocytosis (AG).
  • The results indicate that women may face increased risks of severe outcomes related to FGAs, particularly for TD hospitalization and AG-related deaths, as well as a notable increased risk for Torsades de Pointes (
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Concomitant pain syndromes and cardiovascular disease (CVD) and disorders are associated with significant morbidity, impaired quality of life, and neuropsychiatric disorders. There is an interplay between the mechanisms of pathophysiology of both CVD and pain syndromes. Patients with CVD (and/or disorders) as well as pain syndromes have an increased propensity for drug-drug/disease interactions.

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Introduction: Recent clinical trials evaluating the efficacy of aspirin in primary prevention of atherosclerotic cardiovascular disease (ASCVD) have suggested the risk of aspirin may outweigh its benefit in individuals once thought to be candidates for aspirin therapy. These results led to the publication of updated guideline recommendations in 2019 for aspirin use in primary prevention of cardiovascular disease from the American College of Cardiology (ACC) and American Heart Association (AHA).

Areas Covered: Recent clinical trials and guidelines relevant to aspirin for primary prevention of ASCVD were identified using PubMed® (July 1, 2016 to April 1, 2019).

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Antimicrobial resistance threatens the effective prevention and treatment of many types of infections. Infection occurs more frequently in patients diagnosed with psychiatric illness due to a number of risk factors. Urinary tract infections (UTI) are among the most common infections in this patient population.

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