Publications by authors named "Emily Cutler"
Article Synopsis
- Cancer-associated fibroblasts (CAFs) in B-cell precursor acute lymphoblastic leukemia (B-ALL) originate from bone marrow-derived mesenchymal stromal cells (MSCs) and are influenced by reactive oxygen species from chemotherapy.
- The study shows that exposure of MSCs to B-ALL cells or their secretions initiates the CAF formation, marked by a strong interferon pathway response.
- A key finding is that leukemia cell-derived mitochondrial double-stranded RNA (dsRNA) stimulates MSCs to transition into CAFs, and disrupting dsRNA can block this process, revealing a new way cancer cells interact with their environment.
Cancer Discov
February 2023
Article Synopsis
- Researchers developed a method to create organoids from induced pluripotent stem cells that mimic human bone marrow, which is crucial for studying blood formation and cancers.
- These 3D organoids replicate essential components of bone marrow and support the growth of cancer cells from patients, which are typically hard to maintain in lab settings.
- This innovative platform helps investigate blood cancers and their interactions within the bone marrow environment, aiding in the search for new treatments.
