Universal versus targeted blood cholesterol screening among youth: The CARDIAC project.

Objectives: The goal was to determine the sensitivity and specificity of family history in identifying children with severe or genetic hyperlipidemias in a rural, predominantly white population.

Methods: A total of 20,266 fifth-grade children in West Virginia, from the Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) Project, who completed a family history and fasting lipid profile were used in analyses. The relationship between hyperlipidemia and family history was determined, and the use of family history to predict the need for pharmacologic treatment among children with dyslipidemia was evaluated.

Effects of an exercise intervention using Dance Dance Revolution on endothelial function and other risk factors in overweight children.

Objective: To determine whether an exercise intervention using an active video game (Dance Dance Revolution [DDR]) is effective in improving endothelial dysfunction (EDF) and other risk factors in overweight children.

Design: Thirty-five children (Body mass index > or = 85(th) percentile, mean age 10.21+/-1.