An RNAi screen for ribosome biogenesis genes required for border cell collective migration.

Ribosome biogenesis is critical for the proper production of proteins in cells and has emerged as a regulator of cell invasion and migration in development and in cancer. The border cells form a collective that invades and migrates through the surrounding tissue during oogenesis. We previously found that a significant number of ribosome biogenesis genes are differentially expressed from early to late migration stages.

Transcriptome analysis reveals temporally regulated genetic networks during Drosophila border cell collective migration.

Background: Collective cell migration underlies many essential processes, including sculpting organs during embryogenesis, wound healing in the adult, and metastasis of cancer cells. At mid-oogenesis, Drosophila border cells undergo collective migration. Border cells round up into a small group at the pre-migration stage, detach from the epithelium and undergo a dynamic and highly regulated migration at the mid-migration stage, and stop at the oocyte, their final destination, at the post-migration stage.

High Risk α-HPV E6 Impairs Translesion Synthesis by Blocking POLη Induction.

High risk genus α human papillomaviruses (α-HPVs) express two versatile oncogenes (α-HPV E6 and E7) that cause cervical cancer (CaCx) by degrading tumor suppressor proteins (p53 and RB). α-HPV E7 also promotes replication stress and alters DNA damage responses (DDR). The translesion synthesis pathway (TLS) mitigates DNA damage by preventing replication stress from causing replication fork collapse.

Type of job, personal factors, and disease status are important contextual factors when measuring worker productivity in people with arthritis: a Delphi study.

Arthritis is associated with lost wages, work disability, and decreased productivity. There is a lack of knowledge regarding contextual factors that influence worker productivity to inform rehabilitation. Our study aims to identify the essential contextual factors that need to be considered when measuring worker productivity outcomes in people with arthritis.