AtDGCR14L contributes to salt-stress tolerance via regulating pre-mRNA splicing in Arabidopsis.

In plants, pre-mRNA alternative splicing has been demonstrated to be a crucial tier that regulates gene expression in response to salt stress. However, the underlying mechanisms remain elusive. Here, we studied the roles of DIGEORGE-SYNDROME CRITICAL REGION 14-like (AtDGCR14L) in regulating pre-mRNA splicing and salt stress tolerance.

The Ability of the Invasive Asian Longhorned Tick Haemaphysalis longicornis (Acari: Ixodidae) to Acquire and Transmit Rickettsia rickettsii (Rickettsiales: Rickettsiaceae), the Agent of Rocky Mountain Spotted Fever, Under Laboratory Conditions.

The invasive Asian longhorned tick, Haemaphysalis longicornis Neumann, was first detected in the United States in 2017. It has since been found in 12 states, and there is concern that the tick's parthenogenetic ability and wide variety of host species may allow for broader dissemination. Of the tick-borne diseases endemic to the United States, Rocky Mountain spotted fever (RMSF), a rapidly progressive and potentially fatal disease caused by Rickettsia rickettsii, is the most severe.

A Survey of Key Opinion Leaders to Support Curriculum Development in Advanced Medical Science Liaison Training.

Medical science liaisons (MSLs) are field-based pharmaceutical or biomedical industry professionals whose role demands specialized product knowledge and skill in executing customer-facing activities. This report describes a survey of key opinion leaders (KOLs) to identify MSL skills most highly valued and those in need of enrichment with the objective of designing an advanced training curriculum for experienced MSLs. A total of 66 MSLs representing diverse therapeutic areas verbally administered a 9-question survey at the conclusion of a routine MSL-KOL interaction.

Gleason scores of prostate biopsy and radical prostatectomy specimens over the past 10 years: is there evidence for systematic upgrading?

Background: With the advent of the prostate specific antigen (PSA) assay, an increased detection rate of prostate carcinoma has ensued. This has been associated with a downward stage migration. In contrast, grade has shifted heavily toward moderate differentiation.