Publications by authors named "Emilio Tarcitano"

By establishing multi-omics pipelines, we uncover overexpression and gene copy-number alterations of nucleoporin-93 (NUP93), a nuclear pore component, in aggressive human mammary tumors. NUP93 overexpression enhances transendothelial migration and matrix invasion in vitro, along with tumor growth and metastasis in animal models. These findings are supported by analyses of two sets of naturally occurring mutations: rare oncogenic mutations and inactivating familial nephrotic syndrome mutations.

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Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively low but due to the circular configuration, their stability is very high. In addition, circRNAs display high degree of tissue specificity.

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Article Synopsis
  • HER2 upregulation is linked to worse outcomes in various cancers, highlighting a need for alternative treatments since current anti-HER2 therapies often result in relapses.
  • The study used next-generation sequencing to analyze miRNAs and circRNAs in two breast cancer cell lines, finding 16 miRNAs influenced by HER2 expression, while circRNA levels remained stable.
  • Among these, miR-223-3p, miR-421, and miR-21-5p were validated in a large patient cohort, suggesting they could be new targets to combat HER2 activation.
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Activation of brown adipose tissue (BAT) controls energy homeostasis in rodents and humans and has emerged as an innovative strategy for the treatment of obesity and type 2 diabetes mellitus. Here we show that ageing- and obesity-associated dysfunction of brown fat coincides with global microRNA downregulation due to reduced expression of the microRNA-processing node Dicer1. Consequently, heterozygosity of Dicer1 in BAT aggravated diet-induced-obesity (DIO)-evoked deterioration of glucose metabolism.

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