Publications by authors named "Emilio Ronquillo"
Article Synopsis
- Statin drugs, which help lower cholesterol and prevent cardiovascular disease, may cause adverse effects in women, especially new-onset diabetes and muscle weakness.
- Research in female mice shows that these negative effects are linked to lower levels of the omega-3 fatty acid DHA, as well as issues with cellular function and energy production.
- Administering fish oil to provide DHA can mitigate these adverse effects, and the study suggests that genetic factors related to the X chromosome may increase women's risk, highlighting the potential of DHA supplementation as a helpful therapy.
Males and females differ in body composition and fat distribution. Using a mouse model that segregates gonadal sex (ovaries and testes) from chromosomal sex (XX and XY), we showed that XX chromosome complement in combination with a high-fat diet led to enhanced weight gain in the presence of male or female gonads. We identified the genomic dosage of Kdm5c, an X chromosome gene that escapes X chromosome inactivation, as a determinant of the X chromosome effect on adiposity.
View Article and Find Full Text PDFThe lipin phosphatidic acid phosphatase (PAP) enzymes are required for triacylglycerol (TAG) synthesis from glycerol 3-phosphate in most mammalian tissues. The 3 lipin proteins (lipin 1, lipin 2, and lipin 3) each have PAP activity, but have distinct tissue distributions, with lipin 1 being the predominant PAP enzyme in many metabolic tissues. One exception is the small intestine, which is unique in expressing exclusively lipin 2 and lipin 3.
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