Publications by authors named "Emilio R Salgado"
Biochim Biophys Acta
September 2015
Article Synopsis
- Recombinant erythropoietin (EPO) is used for treating anemia and chronic renal failure, and newer long-acting variants have been developed for less frequent dosing through modifications like glycosylation.
- High levels of EPO were successfully produced in goat's milk using an adenoviral vector, showing that the molecular weight of EPO-Fc affects its hematopoietic activity.
- The study concludes that the types of sugars (sialylated N-glycans) attached to EPO-Fc significantly influence its biological activity in the body, more than just its molecular weight.
