Publications by authors named "Emilio Ortega-Martinez de Victoria"
Cardiovascular risk in type 1 and type 2 diabetes: Differences, similarities and insights.
Endocrinol Diabetes Nutr (Engl Ed)
September 2022
First clinical and efficacy data on evolocumab in routine clinical practice in endocrinology and nutrition services in Spain: A retrospective observational study (RETOSS-ENDO).
Endocrinol Diabetes Nutr (Engl Ed)
September 2022
Background: Cataracts are the main cause of blindness and represent one fifth of visual problems worldwide. It is still unknown whether prolonged statin treatment favors the development of cataracts. We aimed to ascertain the prevalence of cataract surgery in elderly subjects with genetically diagnosed heterozygous familial hypercholesterolemia (HeFH) receiving statin treatment for ≥5 years, and compare this with controls.
View Article and Find Full Text PDFArticle Synopsis
- The study examines how different statins affect LDL cholesterol levels in patients with heterozygous familial hypercholesterolemia (HeFH), a condition that raises cardiovascular risk due to high LDL cholesterol.
- Results showed significant variability in LDL reduction among statins, with rosuvastatin being the most effective, reducing LDL by up to 48.2% compared to simvastatin's 30.2%.
- Those with a confirmed genetic mutation had less response to statins, and about 20% of patients on high-intensity therapy experienced a suboptimal cholesterol reduction.
Hypercholesterolemia and statins are risk factors for aortic stenosis (AS) and vascular calcification, respectively. Whether heterozygous subjects with familial hypercholesterolemia (HeFH) treated with statins are at risk of AS is unknown. We study the prevalence of AS, aortic valve calcification (AoVC), and aortic sclerosis (ASc) in elderly subjects with HeFH in a prolonged statin treatment.
View Article and Find Full Text PDFBackground: LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency of carotid atherosclerotic plaques in patients with LADA as compared with patients with classic type 1 diabetes and type 2 diabetes.
View Article and Find Full Text PDFObjective: In severely obese individuals and patients with diabetes, accumulation and activation of macrophages in adipose tissue has been implicated in the development of obesity-associated complications, including insulin resistance. We sought to determine whether in a healthy population, adiposity, sex, age, or insulin action is associated with adipose tissue macrophage content (ATMc) and/or markers of macrophage activation.
Research Design And Methods: Subcutaneous ATMc from young adult Pima Indians with a wide range of adiposity (13-46% body fat, by whole-body dual-energy X-ray absorptiometry) and insulin action (glucose disposal rate 1.