* A study conducted on 27 P. nobilis individuals from both natural populations and captivity revealed differences in their immune competence, showing that hemolymph from captive animals had a significantly lower Total Hemocyte Count (THC) compared to those from the wild.
* Flow cytometry and ultrastructure analysis indicated that captive pen shells exhibited impaired phagocytosis abilities against pathogens, likely caused by PnPV infection disrupting the hemocyte cyt
There has been significant mass mortality of noble pen shell in various Mediterranean regions over the past seven years linked to a picornavirus that affects immune cells.
A study analyzed specimens from Spain and Italy using electron microscopy and sequencing to identify the virus and understand its impact on the immune cells.
Results showed the virus's presence in 100% of the samples, leading to lower total hemocyte counts and indicating severe immune dysfunction and viral replication in affected animals.
Pinna nobilis is undergoing one of the most dramatic events suffered by an endangered species. An emerging disease has relegated its populations to coastal lagoons or estuaries with salinities beyond the 36.5-39.