Publications by authors named "Emilien Cornillon"
J Bioinform Comput Biol
February 2016
Article Synopsis
- Time is crucial in biological systems like the cell cycle, but identifying parameters in differential equation models is challenging.
- A new hybrid modeling framework is introduced, building on René Thomas' discrete modeling by adding "celerities" to measure time spent in each state.
- This framework constructs a 5-variable model of the mammalian cell cycle, effectively capturing key behaviors such as quiescent phases and endoreplication while determining parameters through formal methods and timing observations.
