Publications by authors named "Emilie van der Sande"
Myopia control in Mendelian forms of myopia.
Emilie van der Sande Jan Roelof Polling J Willem L Tideman Magda A Meester-Smoor Alberta A H J Thiadens
Ophthalmic Physiol Opt
May 2023
Article Synopsis
- High-dose atropine was studied to evaluate its effectiveness in slowing eye growth in children with Mendelian and non-Mendelian myopia, along with a mouse model of myopia.* -
- The treatment resulted in a significant reduction in the annual axial length progression compared to untreated populations, with 27% reduction in Mendelian myopes and 23% in non-Mendelian myopes.* -
- In mice, high-dose atropine also significantly reduced axial length growth, indicating the potential effectiveness of atropine across different genetic causes of myopia.*
Article Synopsis
- * The rise in myopia cases has sparked health concerns due to potential serious eye complications in the future, prompting research into genetic factors through genomewide association studies (GWAS).
- * The gap junction delta-2 (GJD2) gene, which encodes the connexin 36 protein important for retinal signal processing, has been heavily linked to myopia development, with studies exploring its mechanisms involving dopamine and gap junction interactions.