Publications by authors named "Emilie Thiebault"
Article Synopsis
- The insulin receptor (IR) is crucial for insulin signaling, and defects in its function are linked to type 2 diabetes.
- This study explores how the removal of sialic acid from N-glycan chains of the IR affects its function, particularly in 3T3-L1 adipocytes.
- Findings show that desialylation reduces the autophosphorylation activity of the IR and weakens its ability to interact with insulin, potentially contributing to insulin resistance in diabetes.
Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide. While curative approaches for early stage HCC exist, effective treatment options for advanced HCC are lacking. Furthermore, there are no efficient chemopreventive strategies to limit HCC development once cirrhosis is established.
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