Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease.

Background: Neuropsychiatric symptoms (NPS) are frequent in aging and Alzheimer's disease (AD). Here we study the relationship between NPS and AD pathologies in vivo.

Method: Two hundred and twenty-one individuals from the TRIAD cohort (143 cognitively unimpaired, 52 mild cognitive impairment, and 26 AD) underwent [F]MK6240-tau-positron emission tomography (PET), [F]AZD4694-amyloid-PET, magnetic resonance imaging, and neuropsychological evaluations.

Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals.

Introduction: Mild behavioral impairment (MBI) is characterized by the emergence of neuropsychiatric symptoms in elderly persons. Here, we examine the associations between MBI and Alzheimer's disease (AD) biomarkers in asymptomatic elderly individuals.

Methods: Ninety-six cognitively normal elderly individuals underwent MRI, [ F]AZD4694 β-amyloid-PET, and [ F]MK6240 tau-PET.