Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin.

Herein, we describe the myxobacterial natural product Corramycin isolated from Corallococcus coralloides. The linear peptide structure contains an unprecedented (2R,3S)-γ-N-methyl-β-hydroxy-histidine moiety. Corramycin exhibits anti-Gram-negative activity against Escherichia coli (E.

Missense Mutations in the CrrB Protein Mediate Odilorhabdin Derivative Resistance in .

NOSO-502 is a preclinical antibiotic candidate of the Odilorhabdin class. This compound exhibits activity against pathogens, including carbapenemase-producing bacteria and most of the Colistin (CST)-resistant strains. Among a collection of CST-resistant strains harboring mutations on genes , , , and , only those bearing mutations in gene were found to be resistant to NOSO-502.