Ocular surface response of two preservative-free cylcosporine A emulsion eye drops in a mouse model of dry eye.

Purpose/aim: Dry eye (DE) disease is a multifactorial disease in which uncontrolled inflammation can lead to corneal epithelium lesions and symptoms of discomfort. The aim of the present study was to evaluate the efficacy of two cyclosporine emulsions in a mouse model of DE with corneal epithelium lesions.

Materials And Methods: Six- to 9-week-old female C57BL/6 N mice were housed in a controlled-environment room to induce DE.