Publications by authors named "Emilie Gregori"
STAR Protoc
December 2022
Article Synopsis
- The protocol outlines a detailed process for analyzing natural killer (NK) cells from blood samples using mass cytometry.
- It involves three main steps: incubating PBMCs with metal-conjugated antibodies for extracellular profiling, followed by fixation and staining for intracellular proteins, and finally acquiring data using a mass cytometer.
- High-dimensional analysis provides insights into different NK cell subsets and their unique characteristics, with further information available in the referenced study by Chretien et al. (2021).
Proc Natl Acad Sci U S A
June 2021
Article Synopsis
- Natural killer (NK) cells are crucial in fighting leukemia, but their function is hindered by leukemic blasts, leading to the presence of dysfunctional NK cells in acute myeloid leukemia (AML).
- In a study involving patients with newly diagnosed AML, researchers found a significant accumulation of a specific subset of NK cells (CD56CD16) that resemble those seen in HIV-infected individuals, indicating a potential disruption in their activation and function.
- A higher percentage of these CD56CD16 NK cells at diagnosis correlated with poorer clinical outcomes, suggesting they might be a marker for immune evasion as AML progresses.
Article Synopsis
- Researchers are finding that natural killer (NK) cells, which help fight cancer, can help predict how well cancer patients will do, making them important for new treatments.
- In a study of 87 patients with a type of blood cancer called acute myeloid leukemia, three groups of NK cell maturity were identified: hypomaturation (not mature), intermediate, and hypermaturation (very mature).
- Patients with hypomaturation had much worse survival rates compared to those with intermediate or hypermaturation, highlighting how important NK cell maturity is for cancer outcomes.
