Publications by authors named "Emilie E Dencker"
Introduction: Despite the benefits of surgical resection and adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PDAC), over 30 % of patients fail to complete adjuvant oncological treatment. Whether postoperative complications affect chemotherapy completion rates and overall survival remains uncertain. We hypothesized that postoperative complications would be associated with chemotherapy delays, omission, and reduced overall survival (OS).
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- This study evaluates the effectiveness of ICD-10 codes in identifying postoperative complications (PCs) compared to manually reviewing electronic health records (EHRs) using data from 11,827 surgical cases in Denmark.
- Manual curation identified 1,047 PCs, while ICD-10 codes only captured 439, showing a low accuracy of about 20.8% for ICD-10 in detecting these complications.
- The study highlights that PCs significantly increase healthcare resource usage and costs, with findings indicating annual additional costs of €25.5 million, far exceeding estimates based on ICD-10 codes, underscoring the need for better detection methods for surgical quality assessment.
Article Synopsis
- The study aimed to evaluate the effectiveness of natural language processing (NLP) in identifying postoperative complications (pneumonia, urinary tract infection, sepsis, septic shock) compared to traditional administrative data methods.* -
- Data from 17,486 surgical cases across 18 hospitals in Denmark showed that NLP significantly outperformed administrative data, achieving high accuracy rates (receiver operating characteristic areas ranged from 0.989 to 0.998) for identifying these complications.* -
- The findings suggest that NLP can provide more precise detection of postoperative complications, potentially matching manual curation, and could be a useful tool for real-time monitoring in healthcare settings.*
Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers worldwide, with an overall 5-year survival rate of only 5%. The effect of perioperative treatment factors including duration of surgery, blood transfusions as well as choice of anesthesia and analgesia techniques on overall survival (OS) following pancreatic resections for PDAC, is currently not well known. We hypothesized that these perioperative factors might be associated with OS after pancreatic resections for PDAC.
View Article and Find Full Text PDFUnlabelled: To investigate whether pancreatic resections (PR) for pancreatic ductal adenocarcinoma (PDAC) is associated with worse survival when resection of the superior mesenteric vein/portal vein (SMV/PV) is required.
Background: PR for PDAC with resection of the superior mesenteric vein/portal vein (SMV/PV, PR+V resection) may be associated with inferior overall survival (OS) compared with PR without the need for SMV/PV resection (PR-V). We hypothesized that PR+V results in lower OS compared with PR-V.
Introduction: For PDAC patients undergoing resection, it remains unclear whether metastases to the paraaortic lymph nodes (PALN+) have any prognostic significance and whether metastases should lead to the operation not being carried out. Our hypothesis is that PALN + status would be associated with short overall survival (OS) compared with PALN-, but longer OS compared with patients undergoing surgical exploration only (EXP).
Methods: Patients with registered PALN removal from the nationwide Danish Pancreatic Cancer Database (DPCD) from May 1st 2011 to December 31st 2020 were assessed.
Background: Postoperative complications continue to constitute a major issue for both the healthcare system and the individual patient and are associated with inferior outcomes and higher healthcare costs. The objective of this study was to evaluate the trends of postoperative complication rates over a 7-year period.
Methods: The NSQIP datasets from 2012 to 2018 were used to assess 30-day complication incidence rates including mortality rate following surgical procedures within ten surgical subspecialties.