Translational boron neutron capture therapy (BNCT) studies for the treatment of tumors in lung.

Purpose: Boron neutron capture therapy (BNCT) combines selective accumulation of B carriers in tumor tissue with subsequent neutron irradiation. BNCT has been proposed for the treatment of multiple, non-resectable, diffuse tumors in lung. The aim of the present study was to evaluate the therapeutic efficacy and toxicity of BNCT in an experimental model of lung metastases of colon carcinoma in BDIX rats and perform complementary survival studies.