Publications by authors named "Emilia Mc Mazza"
Knowledge of a protein's spatial dynamics at the subcellular level is key to understanding its function(s), interactions, and associated intracellular events. Indoleamine 2,3-dioxygenase 1 (IDO1) is a cytosolic enzyme that controls immune responses via tryptophan metabolism, mainly through its enzymic activity. When phosphorylated, however, IDO1 acts as a signaling molecule in plasmacytoid dendritic cells (pDCs), thus activating genomic effects, ultimately leading to long-lasting immunosuppression.
View Article and Find Full Text PDFArticle Synopsis
- Researchers have discovered that a specific transcription factor, IRF4, is expressed by a subset of CD4+ Tregs in tumors, contributing to their strong immunosuppressive abilities.
- IRF4+ Tregs exhibited higher levels of suppressive molecules and were associated with T cell exhaustion in non-small-cell lung cancer cases.
- Deleting the Irf4 gene in Tregs led to slowed tumor growth in mice, suggesting that targeting this pathway could improve cancer treatment strategies across various tumor types.
Article Synopsis
- Adoptive T cell transfer (ACT) immunotherapy can be enhanced by using early differentiated stem cell memory T (Tscm) cells, which are effective in fighting tumors and can persist for a long time.
- Research shows that less differentiated human CD8+ T cells have a greater ability to protect against oxidative stress compared to more mature T cells.
- The antioxidant N-acetylcysteine (NAC) helps maintain Tscm characteristics during T cell activation, leading to improved long-term memory and stronger antitumor effects when used in ACT, suggesting it could be a valuable addition to treatments.