Publications by authors named "Emilia Lis-Tanas"
Article Synopsis
- Multiple polyposes are complex diseases characterized by the development of cancerous intestinal polyps, with a focus on identifying genetic mutations affecting risk, particularly in Polish patients.
- Researchers studied the p.Q82* mutation in 644 polyposis patients and 634 controls, finding the variant present in some patients, indicating a potential association with increased colorectal cancer risk.
- The study highlights the need for further genetic screening, especially for patients with the homozygous p.Q82* variant, as it appeared more frequently in patients without other identified mutations, suggesting it could be an important marker.
Article Synopsis
- Lower bone mineral density (BMD) is commonly found in inflammatory bowel disease (IBD) patients, and this study focused on the effects of folic acid levels and MTHFR gene polymorphism on BMD in Crohn's disease (CD) and ulcerative colitis (UC) patients compared to healthy controls.
- The analysis showed that IBD patients had significantly lower BMD, T-scores, and Z-scores in both the lumbar spine and femoral neck than the control group, indicating a higher risk for low BMD.
- Although no notable differences in folic acid levels were found between groups, the study suggested that certain MTHFR gene polymorphisms might influence bone density in IBD patients,
Cancer is one of the most common causes of death worldwide. A strong predisposition to cancer is generally only observed in colorectal cancer (5% of cases) and breast cancer (2% of cases). Colorectal cancer is the most common cancer with a strong genetic predisposition, but it includes dozens of various syndromes.
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