Publications by authors named "Emile S"
Background: Current guidelines recommend selective adjuvant chemotherapy for stage II colon cancer with high-risk features. This study aimed to assess survival benefit of adjuvant chemotherapy in patients with stage II colon adenocarcinomas ≥5 cm without high-risk features.
Methods: The National Cancer Database was retrospectively reviewed (2010-2019) for all patients with pathologic stage II colonic adenocarcinomas ≥5 cm who underwent colectomy.
Background: As the population ages, nonagenarian patients with cancer are more frequently treated. This study aimed to assess the characteristics of colon and rectal cancer in patients aged ≥90 years and to evaluate the role of surgical intervention in this age group.
Methods: This retrospective cohort study included nonagenarian patients with colon and rectal cancer identified from the Surveillance, Epidemiology, and End Results (SEER) database from 2000 to 2020.
Background: Limited data exist on long-term outcomes of elective surgery versus nonoperative management of complicated diverticulitis. We aimed to assess long-term outcomes of nonoperative management versus elective surgery in patients initially conservatively treated for diverticulitis.
Methods: Systematic review of PubMed and Scopus for studies comparing elective resection and nonoperative management of acute diverticulitis from inception to December 2023 was conducted.
Introduction: Chatbots have been increasingly used as a source of patient education. This study aimed to compare the answers of ChatGPT-4 and Google Gemini to common questions on benign anal conditions in terms of appropriateness, comprehensiveness, and language level.
Methods: Each chatbot was asked a set of 30 questions on hemorrhoidal disease, anal fissures, and anal fistulas.
Aim: Lymphovascular invasion (LVI) is a well-known risk factor in colorectal cancer that is associated with a worse prognosis. The present study aimed to assess the characteristics of patients with LVI-positive colon cancer according to the status of nodal metastases and to study the association between LVI-nodal status and survival.
Method: This retrospective study assessed the association between LVI and lymph node metastases in colon cancer, using data from the National Cancer Database.
Background: We assessed association among household income, overall survival (OS), and cancer-specific survival (CSS) after proctectomy for rectal cancer.
Methods: Population-based cohort study included stage I-III rectal adenocarcinoma patients who underwent proctectomy (2010-2020), subdivided by household income at diagnosis [low (<$50,000), average ($50,000-74,999), above-average (≥$75,000)] and compared.
Results: Of 39,185 patients (59 % male; mean age 60.
Pelvic exenteration (PE) entails an en bloc resection of locally advanced primary or recurrent rectal cancer. This study aimed to assess the short-term and survival outcomes of minimally invasive (MI)- and open PE. A retrospective cohort analysis of patients with stage III rectal adenocarcinoma treated with PE from the National Cancer Database (2010-2019) was conducted.
View Article and Find Full Text PDFBackground: Management of anorectal cancers requires a multidisciplinary team approach. Recently, large language models have been suggested as potential tools for various applications in health care.
Objective: Assess suggested management recommendations provided by a generative artificial intelligence chatbot with those of a colorectal cancer multidisciplinary team to evaluate applicability in clinical settings.
Background: Lymphovascular invasion (LVI) is an important prognosticator in rectal cancer (RC). We aimed to determine predictors for LVI in RC and incorporate them into a predictive risk score (PRS).
Methods: Case-control analysis of predictors of LVI in RC using data from a national database (2010-2019).
Article Synopsis
- Colorectal anastomotic devices have been used for almost 100 years, with stapled methods being most common, despite a significant leak risk of up to 20%.
- A systematic review and meta-analysis explored newer anastomotic devices, analyzing 18 studies from the last decade, which included 955 anastomoses and focused on non-stapled methods.
- The findings indicated a pooled complication rate of 9.7% for human studies, but new compression mechanisms showed a much lower leak rate of 3.3%, suggesting that these novel technologies could improve surgical outcomes.
Article Synopsis
- This systematic review evaluated how upper gastrointestinal (UGI) dysmotility affects outcomes in patients with colonic inertia (CI) undergoing surgery.
- It found that patients with UGI dysmotility were more likely to experience recurrence of constipation after surgery and had poorer improvements in quality of life compared to those without UGI issues.
- The review suggests routine evaluation of UGI function before surgery for CI, as many patients with UGI dysmotility may go undiagnosed.
Background: Rectal cancer surgery is technically demanding, especially in males. Robotic assistance may help overcome these challenges. This study aimed to identify factors associated with robotic-assisted proctectomy in rectal cancer.
View Article and Find Full Text PDFArticle Synopsis
- Rectal prolapse surgery outcomes were reviewed in predominantly male populations, examining factors like recurrence, complications, and bowel function.
- Eight studies involving 452 male patients showed that abdominal procedures had lower recurrence rates (6%) compared to perineal procedures (19.3%), but longer operative times.
- The best results for improving constipation and fecal incontinence were found after resection rectopexy and posterior mesh rectopexy, respectively.
Background: Tumor deposits are a unique histologic feature of colorectal cancer that is associated with adverse survival outcomes. The present study aimed to assess the association between tumor deposits and liver and lung metastases and to describe the characteristics of colorectal cancer associated with tumor deposits.
Methods: The Surveillance, Epidemiology, End Results (SEER) database was screened between 2010 and 2020 for patients with colorectal adenocarcinoma who underwent radical resection with data on tumor deposits.
Background: Esophageal cancer remains a significant global health challenge. Several treatment modalities were explored in randomized controlled trials (RCTs) in recent decades. This study evaluates the robustness of RCTs focusing on esophageal cancer treatment using the fragility index (FI) and reverse fragility index (RFI).
View Article and Find Full Text PDFBackground: The vast majority of colon cancers occur in pre-existing adenomas. Little is known about the impact of adenoma type on behavior and outcome of subsequent carcinomas. The present study aimed to assess characteristics, behavior, and outcome of colon adenocarcinoma based on histologic type of pre-existing adenoma.
View Article and Find Full Text PDFAim: Anastomotic stricture occurs in up to 30% of colorectal resections; however, evidence on risk factors and preventive measures remains scarce. This study aimed to identify technical factors responsible for increasing the risk for colorectal and coloanal anastomotic strictures.
Method: This was a retrospective cohort study of patients with anastomotic stricture who underwent resection and/or redo anastomosis between January 1, 2011 and August 1, 2021 in a tertiary referral centre.
Article Synopsis
- - A systematic review of studies on Kock pouch (KP) complications found a high overall complication prevalence of 60.4%, with 46.6% requiring revision and 12.9% experiencing failure.
- - Data were collected from 19 studies involving 2042 patients, determining that risk factors for complications included a higher body mass index (BMI) and prior ileoanal pouch anastomosis, but these did not correlate with pouch failure.
- - The findings emphasize that the KP is a complex procedure best performed by skilled surgeons, as many patients still prefer to keep their KP despite complications.