Effect of orientation angle for needle-free jet injection.

In this paper, we report on the delivery efficiency of needle-free jet injections using injectors with typical jet speed v≈140m/s, orifice diameter d=157μm, and volume V=0.1 mL. The target substrates were either hydrogel tissue phantoms or porcine tissues combined with excised human skin.

Effect of air pockets in drug delivery via jet injections.

Needle-free jet injections are actuated by a pressure impulse that can be delivered by different mechanisms to generate high-speed jets (V~O10 m/s). During filling and transportation of disposable cartridges and ampoules, bubbles can form, which can be problematic especially for viscous fluids. Here, we report on the effect of location and size of entrapped air pockets in cartridges used in spring-powered jet injections.