Publications by authors named "Emil Anoop"
Article Synopsis
- Vitamin D deficiency (VDD) is common in the Arab world, including Kuwait, despite high sun exposure, indicating a potential genetic influence alongside lifestyle factors.
- Researchers studied the impact of specific genetic variants (SNPs) in the 25-hydroxylase and GC globulin genes, finding significant correlations with vitamin D levels in Kuwaiti adolescents when adjusting for demographic and lifestyle factors.
- Minor alleles in certain SNPs were linked to lower vitamin D levels, while a specific allele was associated with higher levels and reduced VDD likelihood, suggesting these genetic variants contribute to the prevalence of VDD in the region.
The miR-668 binding site variant rs1046322 on is associated with obesity in Southeast Asians.
Front Endocrinol (Lausanne)
November 2023
Article Synopsis
- The Wolfram syndrome 1 gene is linked to Wolfram syndrome, which causes diabetes, vision loss, and deafness, and may also influence type 2 diabetes (T2D) and metabolic traits through specific gene variants.
- A study on 2067 people from different ethnic backgrounds in Kuwait focused on a particular SNP (rs1046322) and found significant associations between this variant and obesity traits, especially in Southeast Asians (SEA).
- Results showed that SEA individuals carrying the effect allele had higher body mass index (BMI), waist circumference, and triglyceride levels, highlighting how ethnic background impacts the effect of genetic factors on metabolic diseases.
ANGPTL3 is an important regulator of lipid metabolism. Its inhibition in people with hypercholesteremia reduces plasma lipid levels dramatically. Genome-wide association studies have associated ANGPTL3 variants with lipid traits.
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