Comparison of spinal cord contusion and transection: functional and histological changes in the rat urinary bladder.

Objective: To compare the effect of complete transection (tSCI) and contusion spinal cord injury (cSCI) on bladder function and bladder wall structure in rats.

Materials And Methods: A total of 30 female Sprague-Dawley rats were randomly divided into three equal groups: an uninjured control, a cSCI and a tSCI group. The cSCI group underwent spinal cord contusion, while the tSCI group underwent complete spinal cord transection.

Simultaneous implantation of bilateral ureters into bladder acellular matrix graft after partial cystectomy in a porcine model.

Unlabelled: What's known on the subject? and What does the study add? The process of bladder regeneration with a bladder acellular matrix graft (BAMG) is thought to be accelerated by administration of vascular endothelial growth factor into the host bladder. In the present study, we showed that simultaneous implantation of bilateral ureters into a BAMG after a partial cystectomy is reasonable and provides an increased opportunity to the bio-scaffold for communication with host tissues from which a blood supply and stem cells will be generated.

Objective: • To evaluate if the implantation of bilateral ureters into a bladder acellular matrix graft (BAMG) at the time of its implantation would enhance bladder regeneration in a partial substitution BAMG.

Mechanism of continence after repair of posterior urethral disruption: evidence of rhabdosphincter activity.

Purpose: Controversy exists regarding continence mechanisms in patients who undergo posterior urethral reconstruction after pelvic fracture. Some evidence suggests that continence after posterior urethroplasty is maintained by the bladder neck or proximal urethral mechanism without a functioning distal mechanism. We studied distal urethral sphincter activity in patients who have undergone posterior urethroplasty for pelvic fracture.

Functional improvement in spinal cord injury-induced neurogenic bladder by bladder augmentation using bladder acellular matrix graft in the rat.

Spinal cord injury (SCI) rostral to the lumbosacral level causes bladder hyperreflexia and detrusor-sphincter dyssynergia (DSD), which are accompanied by bladder hypertrophy. We hypothesize that bladder augmentation using a bladder acellular matrix graft (BAMG) can improve the function of SCI-mediated neurogenic bladder. In female rats (n = 35), SCI was induced by transection of the spinal cord at the lower thoracic level.

The effect of intracavernosal growth differentiation factor-5 therapy in a rat model of cavernosal nerve injury.

Objective: To determine whether the intracavernosal application of growth differentiation factor-5 (GDF-5) influences nerve regeneration and erectile function after cavernosal nerve injury in a rat model.

Materials And Methods: Thirty-two male Sprague-Dawley rats were randomly divided into four equal groups: eight had a sham operation (uninjured controls), while 24 had bilateral cavernosal nerve crush. The crush-injury groups were treated at the time of injury with an impregnated collagen sponge implanted into the right corpus cavernosum.

Collagen I:III ratio in canine heterologous bladder acellular matrix grafts.

The objective of this study was to investigate the limitations of a heterologous bladder acellular matrix graft (BAMG) and the influence of the collagen ratio on functional regeneration in a large animal model. Ten female dogs underwent partial cystectomy; eight received BAMG (two homologous; six heterologous) and two partial cystectomy only. A cystometry was performed prior to surgery and 7 months postoperatively when all animals underwent sacral root stimulation.

Effect of vascular endothelial growth factor on regeneration of bladder acellular matrix graft: histologic and functional evaluation.

Objectives: To evaluate the effect of vascular endothelial growth factor (VEGF) on regeneration of the bladder acellular matrix graft (BAMG).

Methods: A total of 40 female rats were divided into two groups. In the experimental group (VEGF+), the BAMG was incubated in VEGF and VEGF was injected into the host bladder.

Neuromodulation in voiding dysfunction: a historical overview of neurostimulation and its application.

This article presents a historical overview of neurostimulation and its application in voiding dysfunction.

Homologous acellular matrix graft for vaginal repair in rats: a pilot study for a new reconstructive approach.

The purpose of this paper is to investigate using an acellular matrix graft of vagina (VAMG) or bladder (BAMG) in vaginal reconstruction. In 18 rats, vaginal length was measured and a hysterectomy performed. In three control animals, the vaginal stump was closed.

The bladder acellular matrix graft in a rat chemical cystitis model: functional and histologic evaluation.

Purpose: We investigated the feasibility of augmentation in a diseased bladder with a bladder acellular matrix graft.

Materials And Methods: In 50 female Sprague-Dawley rats chemical cystitis was induced by intravesical instillation of HCl repeated monthly to maintain chronic inflammation. Urodynamic studies were performed in all rats 1 week after the induction of chemical cystitis and repeated at sacrifice.

Physiologic bladder evacuation with selective sacral root stimulation: sinusoidal signal and organ-specific frequency.

In patients with spinal cord injury above S2, who characteristically have both detrusor hyperflexia and sphincteric spasm, sacral anterior root stimulation can evacuate the bladder, but sacral deafferentation is needed to eliminate the hyperreflexia for normal bladder filling. The common stimulation parameters for these patients activate the detrusor and the external urethral sphincter simultaneously (detrusor-sphincter dyssynergia), and the resultant post-stimulus voiding is not physiologic. We sought to determine organ-specific stimulation parameters.