Publications by authors named "Emigdio Alvarez-Corrales"
Diffuse large B cell lymphoma (DLBCL) is the most common aggressive B cell lymphoma and accounts for nearly 40% of cases of B cell non-Hodgkin lymphoma. DLBCL is generally treated with R-CHOP chemotherapy, but many patients do not respond or relapse after treatment. Here, we analyzed the therapeutic potential of the tumor suppressor microRNA-28 (miR-28) for DLBCL, alone and in combination with the Bruton's tyrosine kinase inhibitor ibrutinib.
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- Naïve CD4 T cells require different signals during activation to elicit a proper immune response, and this study focused on their behavior after stimulation for 14 days.
- The findings revealed that activated CD4 T cells showed increased glucose needs and developed a pathogenic Th17 profile, indicating a potential flexibility towards a Th17/1 phenotype, while regulatory T cells did not appear functional.
- The study also highlighted the role of the vasoactive intestinal peptide (VIP) system, which was found to modulate gene expressions related to Th17 stabilization and plasticity, underlining VIP's importance in T cell responses in various conditions.