Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga .

Eight new (-) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds and were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC values 15 and 16 μM, respectively.

Alkaloids of the Lauraceae.

This chapter presents an overview of the chemistry and pharmacology of the alkaloids found in species of the Lauraceae family. The occurrence of alkaloids from Lauraceae species as well as their chemical structures is summarized in informative and easy-to-understand tables. Within the Lauraceae family, the genera Ocotea (195), Litsea (180), Cryptocarya (133), and Neolitsea (110) have led to the greater number of publications regarding alkaloids content.

Pimarane diterpenes and a sesquiterpene from Salzmmania nitida.

Two new terpenoids, (+)-3-oxo-thermarol and 11-acetoxyeudesman-4alpha-methyl-5alpha-ol along with the (+)- thermarol were isolated from the aerial parts of Salzmmania nitida. The structures and unambiguous 1H and 13C chemical shift assignments were established by spectroscopic means, including homo and heteronuclear techniques.

Roraimine: a bisbenzylisoquinoline alkaloid from Cissampelos sympodialis roots.

The roots of Cissampelos sympodialis yielded Roraimine (1), a novel bisbenzylisoquinoline alkaloid and liriodenine (2), a known oxoaporphine alkaloid.