Publications by authors named "Emi Tsuchitani"
Genome editing techniques such as CRISPR/Cas9 have both become common gene engineering technologies and have been applied to gene therapy. However, the problems of increasing the efficiency of genome editing and reducing off-target effects that induce double-stranded breaks at unexpected sites in the genome remain. In this study, we developed a novel Cas9 transduction system, Exci-Cas9, using an adenovirus vector (AdV).
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- Novel therapies targeting BET proteins have shown promise in treating various cancers but resistance mechanisms are not well understood.
- In the study, U937 cells treated with the BET inhibitor I-BET151 exhibited growth inhibition and apoptosis, while I-BET151-resistant U937R cells did not show these effects.
- Combining I-BET151 with an IKK inhibitor improved apoptosis in both cell types and suggested that the resistance in U937R cells is linked to increased NF-κB signaling through BRD2 and BRD4 expression, indicating a potential therapeutic strategy to combat this resistance.