Publications by authors named "Emi Takakusagi"
Article Synopsis
- At the start of anaphase, the enzyme separase breaks apart sister chromatids by cleaving the cohesin subunit Scc1, a process that is regulated by the degradation of the inhibitor securin and the phosphorylation of Scc1 by polo-like kinase (Plk) 1.
- The study focuses on the role of budding yeast Plk1, known as Cdc5, which interacts with cohesin during the G2/M phase, and this interaction relies on specific phosphorylations on Scc1.
- While altering the phosphorylation sites on Scc1 affects Cdc5's ability to bind cohesin, it only slightly impacts cell growth, but makes the cells more sensitive to DNA damage, highlighting that phosphorylation
