Functional characteristics of a renal H/lipophilic cation antiport system in porcine LLC-PK cells and rats.

We have recently found an H/quinidine (a lipophilic cation, QND) antiport system in Madin-Darby canine kidney (MDCK) cells. The primary aim of the present study was to evaluate whether the H/lipophilic cation antiport system is expressed in porcine LLC-PK cells. That is, we investigated uptake and/or efflux of QND and another cation, bisoprolol, in LLC-PK cells.