Publications by authors named "Emi Ando"
In the developing liver, bile duct structure is formed through differentiation of hepatic progenitor cells (HPC) into cholangiocytes. A subtype of polycystic liver diseases characterized by uncontrolled expansion of bile ductal cells is caused by genetic abnormalities such as in that of protein kinase C substrate 80 K-H (PRKCSH). In this study, we aimed to mimic the disease process in vitro by genome editing of the PRKCSH locus in human inducible pluripotent stem (iPS) cells.
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- The liver plays a crucial role in maintaining balance in the body, but its functions and how it processes drugs can vary between sexes due to differences in enzyme expression.
- The study identifies B-cell lymphoma 6 (Bcl6) as a key factor influencing these sex-biased differences in liver enzymes (CYPs) that metabolize drugs.
- Results show that knocking out Bcl6 in male mice alters their liver enzyme expression to resemble that of females, indicating Bcl6's critical role in regulating sex differences in drug metabolism without affecting overall sex characteristics.
[GC-MS analysis of methamphetamine and amphetamine in hair of Thai drug addicts].
Nihon Arukoru Yakubutsu Igakkai Zasshi
June 2004
Unlabelled: Psycho-stimulant dependence in young individuals has become a serious problem in Thailand, where consumption of the so-called YaBa methamphetamine tablets has become a fashionable trend. Due to its easy availability in the form of a tablet, young individuals abuse methamphetamine. Methamphetamine tablets are known to be potently addictive and its difficulty in cessation of drug use and to be abstinent from the drug.
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