Publications by authors named "Emery Lu"
Many developmental signaling pathways have been implicated in lineage-specific differentiation; however, mechanisms that explicitly control differentiation timing remain poorly defined in mammals. We report that murine Hedgehog signaling is a heterochronic pathway that determines the timing of progenitor differentiation. Hedgehog activity was necessary to prevent premature differentiation of second heart field (SHF) cardiac progenitors in mouse embryos, and the Hedgehog transcription factor GLI1 was sufficient to delay differentiation of cardiac progenitors in vitro.
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- Lung progenitor cells are essential for lung regeneration after injury, but their ability to effectively engraft when transplanted is uncertain.
- In a study, researchers transplanted two types of lung progenitor organoid cells into injured mouse lungs: SCA1-negative organoid cells (SNO), which stayed in alveolar areas, and SCA1-positive progenitor cells (SPO), which integrated into both airway and alveolar regions.
- The findings indicate that SNO cells behave like native AT2 cells, while SPO cells show signs of both alveolar and airway cell characteristics, suggesting their potential use for studying lung disease and cell regeneration.