Publications by authors named "Emem Edet-Amana"
Amyotroph Lateral Scler
June 2012
Article Synopsis
- A longitudinal study examined changes in the neuromuscular junction of SOD1-G93A mice, focusing on histological and biochemical markers of muscle function and the effects of the heat shock protein inducer, arimoclomol.
- Findings revealed that denervation and nerve sprouting began as symptoms appeared, with a decline in cholinergic enzyme activities and alterations in muscle fiber characteristics, particularly in fast muscles.
- Treatment with arimoclomol not only delayed these harmful changes but also improved muscle innervation and enzyme activities, along with increased Hsp70 expression, suggesting a potential therapeutic strategy for ALS.
