Publications by authors named "Emeline Thevenon"
Article Synopsis
- Lupus nephritis, a severe complication of systemic lupus erythematosus, is characterized by IgG immune complex deposition in the kidneys and has few treatment options.
- The study explores the roles of kidney macrophages, highlighting differences between tissue-resident macrophages (TrMacs) and monocyte-derived macrophages (MoMacs) in responding to the disease.
- It was found that TrMacs are involved in recruiting other immune cells and supporting B cells, while MoMacs actively take up and present immune complexes, suggesting a specialized function for each macrophage subset in the pathology of lupus nephritis.
Antibody responses deeply rely on the interaction of antigen-primed B cells and CD4 helper T cells in the context of germinal center reactions, through signals provided by costimulatory molecules and cytokines. B-cell proliferation and differentiation in antibody-secreting plasma cells are processes that critically depend on the helper function of a specific CD4 T-cell subset, known as follicular helper T cells (Tfh). Here, we describe a method that mimics in vitro the cross talk between Tfh and B cells occurring in the germinal center.
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