Publications by authors named "Emeline Maisonneuve"

During pregnancy, the mother's IgG immunoglobulins cross the -placenta via the neonatal Fc receptor (FcRn), enabling the fetus to acquire passive immunity. In the presence of maternal allo- or auto-antibodies, placental transfer of these pathogenic antibodies mediated by FcRn can cause diseases in the fetus and/or the newborn. FcRn blockade therefore appears to be a therapeutic strategy in these high-risk pregnancies, firstly by reducing IgG recycling, -thereby reducing its concentration in the maternal circulation, and secondly by blocking placental transfer.

View Article and Find Full Text PDF

Objective: To assess the association between clinical chorioamnionitis and neurodevelopmental disorders at 5 years of age in children born preterm.

Study Design: EPIPAGE 2 is a national, population-based cohort study of children born before 35 weeks of gestation in France in 2011. We included infants born alive between 24 and 34 weeks after preterm labor or preterm premature rupture of membranes.

View Article and Find Full Text PDF

Introduction: Fetal anemia from hemolytic disease treated by intrauterine transfusion (IUT) can be performed by intraperitoneal, intracardiac, and intravascular transfusion (IVT). Objective of our study was to compare different transfusion techniques.

Methods: Retrospective review of IUT secondary to red cell alloimmunization was conducted at eight international centers from 2012 to 2020.

View Article and Find Full Text PDF

The lack of inclusion of pregnant women in clinical trials evaluating the effectiveness of medicines to treat COVID-19 has made it difficult to establish evidence-based treatment guidelines for pregnant women. Our aim was to provide a review of the evolution and updates of the national guidelines on medicines used in pregnant women with COVID-19 published by the obstetrician and gynecologists' societies in thirteen countries in 2020-2022. Based on the results of the RECOVERY (Randomized Evaluation of COVID-19 Therapy) trial, the national societies successively recommended against prescribing hydroxychloroquine, lopinavir-ritonavir and azithromycin.

View Article and Find Full Text PDF

Objectives: This study aimed to evaluate the risk of congenital malformation among pregnant women exposed to the mRNA COVID-19 vaccines during the first trimester of pregnancy, which is a developmental period where the foetus is at risk of teratogenicity.

Methods: Pregnant women were prospectively enrolled from March 2021 to March 2022, at the time of COVID-19 vaccination. Pregnant women exposed to at least one dose of mRNA COVID-19 vaccine from conception to 11 weeks of gestations and 6 days were compared with pregnant women exposed to the vaccine from 12 weeks to the end of pregnancy.

View Article and Find Full Text PDF

With COVID-19 vaccination hesitancy at around 50% in the obstetric population, it is critical to identify which women should be addressed and how. Our study aimed to assess COVID-19 vaccination willingness among pregnant and postpartum women in Europe and to investigate associated determinants. This study was a cross-sectional, web-based survey conducted in Belgium, Norway, Switzerland, The Netherlands, and United Kingdom (UK) in June-August 2021.

View Article and Find Full Text PDF

Background: The incidence of diabetes mellitus (both pregestational and gestational) is increasing worldwide, and hyperglycemia during pregnancy is associated with adverse pregnancy outcomes. Evidence on the safety and efficacy of metformin during pregnancy has accumulated resulting in an increase in its prescription in many reports.

Aims: We aimed to determine the prevalence of antidiabetic drug use (insulins and blood glucose-lowering drugs) before and during pregnancy in Switzerland and the changes therein during pregnancy and over time.

View Article and Find Full Text PDF
Article Synopsis
  • SARS-CoV-2 positive pregnant women have a varying risk of severe maternal adverse outcomes depending on the circulating variant, with higher risks during the Delta variant wave.
  • A study of 2055 unvaccinated pregnant women from March 2020 to September 2022 showed 3.4% had severe outcomes in the pre-Delta period, increasing to 6.5% during Delta, and decreasing to 1.0% during Omicron.
  • The study also highlighted that pregnancy complications were common across all periods, with stillbirth rates rising significantly during the Delta wave.
View Article and Find Full Text PDF

Aim: The objective of this study was to describe the use of COVID-19-related medicines during pregnancy and their evolution between the early/late periods of the pandemic.

Methods: Pregnant women who tested positive for SARS-CoV-2 from March 2020 to July 2021 were included using the COVI-PREG registry. Exposure to the following COVID-19-related medicines was recorded: antibiotics, antivirals, hydroxychloroquine, corticosteroids, anti-interleukin-6 and immunoglobulins.

View Article and Find Full Text PDF
Article Synopsis
  • Pyruvate Kinase (PK) deficiency is a common enzyme defect that leads to congenital hemolytic anemia, often evident from birth.
  • A family with a history of PK deficiency underwent prenatal management for their third child after previous complications from the condition; ultrasound monitoring helped identify severe fetal anemia, resulting in two intrauterine red blood cell transfusions.
  • Successful treatment allowed the third child to be born healthy, emphasizing the importance of fetal monitoring and management in families with a diagnosed proband for PK deficiency.
View Article and Find Full Text PDF

Objective: To provide recommendations on the management of urgent obstetrical emergencies outside the maternity ward.

Design: A group of 24 experts from the French Society of Emergency Medicine (SFMU), the French Society of Anaesthesia and Intensive Care Medicine (SFAR) and the French College of Gynaecologists and Obstetricians (CNGOF) was convened. Potential conflicts of interest were formally declared at the outset of the guideline development process, which was conducted independently of industry funding.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the safety of mRNA COVID-19 vaccines in pregnant women in Switzerland, focusing on adverse events and pregnancy outcomes after vaccination from March to December 2021.
  • - Among 1,012 vaccinated women, most reported local pain after shots, but severe adverse events were rare, with only four reported cases (0.4%) including pulmonary embolism and fever.
  • - Notably, the rates of spontaneous abortions and stillbirths were low, and while some women delivered preterm, no stillbirths occurred among those vaccinated during pregnancy.
View Article and Find Full Text PDF

Objectives: The aim of the study was to report a subtype of dysraphism designated as myelic limited dorsal malformation (MyeLDM) and to describe its characteristics at prenatal ultrasound (US).

Methods: It was a retrospective study from 2014 to 2020 based on second-line US evaluation of patients referred to our institution for myelomeningocele (MMC). Magnetic resonance imaging and acetylcholine esterase evaluation in the amniotic fluid were also offered.

View Article and Find Full Text PDF

Background And Objectives: Anti-c is the third red blood cell antibody responsible for haemolytic disease of the foetus and newborn (HDFN) requiring intrauterine transfusion. We aimed to identify risk factors associated with HDFN and severe HDFN due to Rhc maternal-foetal incompatibility.

Materials And Methods: A retrospective cohort study was conducted in Paris and the surrounding area (France), between 2013 and 2015.

View Article and Find Full Text PDF

Vitamin D deficiency affects more than half of the general population. During pregnancy vitamin D insufficiency is associated with a higher risk of complications such as an increased incidence of miscarriages. Preterm delivery, preeclampsia, gestational diabetes, growth retardation and low birth weight as well as postpartum hemorrhage are all pathologies whose incidence seems to be increased with hypovitaminosis D.

View Article and Find Full Text PDF

Introduction: Open fetal myelomeningocele (MMC) surgery is currently the standard of care option for prenatal MMC repair. We described the population referred to our center and reviewed outcome after open fetal MMC repair.

Material And Methods: All patients referred to our center for MMC were reviewed from July 2014 to June 2020.

View Article and Find Full Text PDF

Background: Red blood cell alloimmunization is the first cause of fetal and neonatal anemia. Alloimmunizations with anti-PP1P or anti-P can cause recurrent miscarriages and hemolytic disease of the fetus and newborn in the 2nd and 3rd trimesters of pregnancy. We report on a pregnant patient immunized with anti-P and a history of recurrent miscarriages.

View Article and Find Full Text PDF

Background: Early intrauterine transfusion (IUT) is associated with a higher risk of fetal loss. Our objective was to evaluate the efficiciency of intravenous immunoglobulins (IVIG) to postpone the gestational age at first IUT beyond 20 weeks of gestation (WG) compared to the previous pregnancy in case of very severe red blood cell (RBC) alloimmunization.

Study Design And Methods: Very severe RBC alloimmunization was defined by a high titer of antibodies and a previous pregnancy complicated by a first IUT before 24 WG and/or perinatal death directly related to alloimmunization.

View Article and Find Full Text PDF

Background: The pathogenesis of late-onset sepsis (LOS) in preterm infants is poorly understood and knowledge about risk factors, especially prenatal risk factors, is limited. This study aimed to assess the association between the cause of preterm birth and LOS in very preterm infants.

Methods: 2052 very preterm singletons from a national population-based cohort study alive at 72 h of life were included.

View Article and Find Full Text PDF