Publications by authors named "Emeline Bequet"
At a clinical level, ileal and colonic Crohn's disease (CD) are considered as separate entities. These subphenotypes need to be better supported by biological data to develop personalised medicine in CD. To this end, we combined different technologies (proximity extension assay, selected reaction monitoring, and high-sensitivity turbidimetric immunoassay (hsCRP)) to measure 207 immune-related serum proteins in CD patients presenting no endoscopic lesions (endoscopic remission) (n = 23), isolated ileal ulcers (n = 17), or isolated colonic ulcers (n = 16).
View Article and Find Full Text PDFBackground: The inactive dephosphorylated and uncarboxylated form of the matrix Gla protein (dp-ucMGP) has been shown to be increased in plasma of inflammatory bowel disease (IBD) patients. Our aim was to assess if the plasmatic level of dp-ucMGP could reflect disease endoscopic activity, presence of strictures and cumulative structural bowel damage in Crohn's disease (CD) patients.
Methods: The plasmatic level of dp-ucMGP was measured in a monocentric cohort of prospectively recruited patients.
Background: Ileal and colonic Crohn's disease seem to be two separate entities.
Aims: To describe the main physiological distinctions between the small and the large intestine and to analyse the differences between ileal and colonic Crohn's disease.
Methods: The relevant literature was critically examined and synthesised.
Article Synopsis
- - The study investigates how intestinal fibrosis in Crohn's disease (CD) is linked to epithelial cells, focusing on the role of endoplasmic reticulum (ER) stress and specific proteins, particularly AGR2.
- - Researchers analyzed the proteome of intestinal surface epithelium from areas of fibrosis and confirmed findings through immunohistochemistry in various CD and control samples.
- - Results indicate that ER stress in epithelial cells leads to increased AGR2 secretion, which promotes the differentiation of fibroblasts into myofibroblasts, contributing to the development of strictures in CD.
Article Synopsis
- * An international study of 72 CLD patients found that 17% also had IBD, with a notably higher prevalence compared to general European rates, indicating a potential relationship between CLD and IBD.
- * Patients with both CLD and IBD often have growth issues and may require surgical interventions, highlighting the need for attentive management of these patients' health.